Job Summary:

3D Systems, through the 2021 announced acquisition of Volumetric, is expanding our collaborative bioprinting program to leverage progress made on the bioprinting of lung scaffolds for application across human kidney and liver scaffolds. We are seeking Organ Biologists for Cell Production & R&D that will operate out of our collaborator’s site in Manchester, NH.

The Organ Biologist, Cell Production & R&D (3DS) will lead efforts in developing and implementing robust process methods for the differentiation of iPS-derived cells into kidney or liver cell types for development of autologous 3D printed tissue engineered kidneys and livers. The incumbent will also be tasked with primary cell isolation and expansion of various kidney or liver cell types from human tissue in support of cellularization efforts.

We seek candidates who can apply their experience, analysis, and creative thinking to solve new, cutting-edge problems in regenerative medicine.

Essential Job Duties & Responsibilities:

• Lead the development and implementation of robust process methods for the production and characterization of primary and/or iPS-derived cells for tissue engineering of human kidneys or livers
• Contribute to the production and characterization efforts to provide sufficient cells (primary and iPS derived) for R&D cellularization efforts of 3D printed scaffolds
• Contribute to academic and industry collaborations and facilitate tech transfer activities from outside collaborators to internal laboratory
• Contribute to the development and implementation of analytic methods to characterize quality and suitability of iPS-derived cells for generation of 3D printed organs
• Design and execute laboratory experiments that lead to the successful achievement of program objectives
• Foster and leverage synergistic interactions with other sub-groups in Organ Manufacturing (e.g., Bioink, Scaffold Production, Cellularization) and with collaborators, as needed
• Participate in selection, purchase, and implementation of laboratory equipment
• Develop, write and review laboratory methods and protocols
• Assist in the effective tech transfer activities from outside collaborators to internal laboratory
• Assist in evaluating new technologies for future process development
• Interact with manufacturing team to ensure process and methods for production of iPS-derived cells are GMP ready
• Author and contribute to scientific publications and present data at scientific conferences
• Author and contribute to IP and regulatory filings
• Perform all other duties as assigned

Education and Training:

• Master’s degree (MA/MS/MBA) in Biomedical engineering, Cell Biology, Molecular Biology (or equivalent) OR
• Doctor of Philosophy (PhD) in Biomedical engineering, Cell Biology, Molecular Biology (or equivalent)

Experience:

• Preferred 5+ years of relevant experience including experience in stem cell differentiation (preferably of kidney or liver cell types), bioreactor cell production scale up, regenerative medicine, tissue engineering (with a Master's Degree)
• Preferred 2+ years of relevant experience including experience in stem cell differentiation (preferably of kidney or liver cell types), reprogramming, bioreactor cell production scale up, regenerative medicine, tissue engineering (with a PhD)
• Proven ability to analyze biological statistics, draw conclusions and clearly report results and suggested next steps.
• Comfortable multi-tasking in a fast-paced and cross-functional environment with ability to work independently to deliver results.

Knowledge, Skills & Abilities:

• Required - Technical expertise in iPSC differentiation methods (kidney or liver preferred)
• Preferred - Technical expertise in small scale cell bioreactor culture including Ambr systems and vertical wheel bioreactors
• Preferred - Expertise in automated cell processing equipment such CliniMACS Plus, LOVO, Cue, Sepax, Sefia, Rotea and others
• Preferred - Knowledge in transfer of R&D cell expansion methods to GMP
• Required - Facility with appropriate word processing, spreadsheet, presentation and related standard software; Experience with laboratory instrumentation and data software
• Required - Ability to lead, mentor and motivate team members
• Required - Advanced written and oral communication skills
• Required - Ability to lift up to 10 pounds regularly, reaching, seeing fine details, and operating in a lab setting

Travel:

Up to 20% travel to collaborators and relevant conferences. Travel to 3D System sites in Houston, TX and San Diego, CA, as needed.