ORBIT ( Oncology Research for Biologics and Immunotherapy Translation) is a platform under the Therapeutics Discovery Division at MD Anderson Cancer Center (MDACC), Houston, Texas. MDACC is a recognized leader in the discovery and development of innovative therapies that help patients to prevail over cancer disease. ORBIT is a centralized MDACC platform that guides, inform, accelerate and execute the translation of novel discoveries into clinically relevant cancer bio-therapeutics. We are committed to biologics development with industry standard and aim line of sight for combining scientific excellence with commercialization.

We are seeking a highly motivated Institute Research Investigator to join our efforts in discovery and development of novel anti-cancer biologics. The successful candidate is expected to be a bench scientist and will use a wide range of techniques in monoclonal antibody generation, screening and characterization from lead identification, optimization and clinical candidate selection. This individual will have a broad knowledge in the field of protein science and will collaborate with other team members to advance our programs in the pipeline. Previous experience in biotech and/or pharma specialized in antibody discovery and development projects is highly preferred.

Key responsibilities:

• Perform protein/antibody expression, purification, and analytical characterization for therapeutic targets
• Complete antibody library generation, screening assays, and antibody engineering for humanization, affinity maturation and lead optimization
• Perform analytical characterization of antibody and its interaction with antigen using state of the art technologies, i.e., SPR/OCTET and UHPLC-SEC
• Run LC-MS/MS for large molecules and MRM/SRM for peptide quantifications
• Generate and screen therapeutic antibodies using hybridomas, single B-cloning technology or related technologies
• Perform molecular biology techniques for HTP cloning and expression plasmid constructions
• Contribute to write technical reports for patent applications, IND reports and scientific publications
• Record and present data & findings in a timely manner to leadership team
• Assist and guide associate scientists to strategize work flow to reach milestones

Skills:

• Strong communication abilities in both writing and verbal are essential

• Strong organizational skills including the ability to manage several projects simultaneously are required

• Dedication, focus, quick learning abilities, and the aptitude to multitask are desirable

• Intellectually curious and well informed on the latest scientific advances in the field are preferred qualities
• Demonstrated creativity and novel approaches to solving scientific problems is ideal
• Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required
• Detail-oriented with excellent record-keeping skills is required

EDUCATION:
Required: Bachelor's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.

EXPERIENCE:
Required: Six years experience of relevant research experience in laboratory With Master's degree, four years of required experience. With a PhD in a natural science or Medical degree, no experience required.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

Additional Information

• Requisition ID: 157843
• Employment Status: Full-Time
• Employee Status: Regular
• Work Week: Days
• Minimum Salary: US Dollar (USD) 96,500
• Midpoint Salary: US Dollar (USD) 121,000
• Maximum Salary : US Dollar (USD) 144,750
• FLSA: exempt and not eligible for overtime pay
• Fund Type: Soft
• Work Location: Onsite
• Pivotal Position: Yes
• Referral Bonus Available?: Yes
• Relocation Assistance Available?: Yes
• Science Jobs: Yes

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